Searchable abstracts of presentations at key conferences on reproductive biology and medicine

ra0003o011 | Oral Communications 2: Early Development 1 | SRF2016

Investigating O-GlcNAcylation in an in vitro model used to mimic diabetes, and its effects on implantation

Watts Jessica , Ruane Peter , Aplin John , Westwood Melissa

The incidence of diabetes has increased in recent decades and by 2030, 366 million people worldwide will have the disease a significant proportion of these will be women of reproductive age. Diabetes is known to reduce fecundity and increase the likelihood of early pregnancy loss we propose that the high glucose levels seen in diabetes influence maternal fertility by impairing endometrial receptivity/function as a result of increased flux in the hexosamine biosynthetic pathway...